Bears alive, but need help heading into final Sunday

The defensive end after the Bears beat the Cardinals 28-13 on Sunday.

GLENDALE, Ariz. — They're alive.

Only because they faced an offense far more disjointed than their own were the Bears able to withstand another lethargic start. Jump-started by two defensive touchdowns — their first since Week 9 — the Bears trounced the woeful Cardinals on Sunday at University of Phoenix Stadium.

The 28-13 victory improved the Bears to 9-6 and kept them in the NFC playoff race. They need to win the regular-season finale against the Lions in Detroit on Sunday and have the Packers defeat the Vikings at the Metrodome to claim a wild-card spot. The Bears have won eight of their last nine vs. the Lions, who will look to be a spoiler while trying to get wide receiver Calvin Johnson 2,000 yards on the season. He needs 108.

The Packers will be motivated against the Vikings with a first-round bye and the No. 2 seed in the NFC on the line.

"I've always been a big Packers fan," Bears coach Lovie Smith said. "It's not hard at all for me. We have a tough division, but as we said this week, we can't do much about that. All we can do is get a win against Detroit."

Reserve cornerback Zack Bowman, playing against the Cardinals' heavy package, recovered a fumble by Beanie Wells for the first score of the game and Charles Tillman returned an interception 10 yards for a touchdown in the third quarter, the Bears' ninth defensive touchdown of the season, leaving them one behind the 1998 Seahawks for the most in NFL history.

Those plotting an end to the Smith era have to hold on now. Most consider it unlikely the Bears will have a housecleaning project under general manager Phil Emery if the club reaches the playoffs. Emery has spoken publicly only once since the season began, during the off week.

But the Bears are not going to go anywhere in the postseason if the offense doesn't find a level of consistency. Running back Matt Forte once again is nursing a right ankle injury as he was knocked out of the game in the third quarter after carrying 12 times for 88 yards, including a 4-yard touchdown. Wearing a walking boot afterward, he declared he would play against the Lions, but it is too early to know.

"With running lanes like that, you can make moves in the open field and get extra yards," Forte said. "It is unfortunate I had to leave the game, but I felt like we were really starting to roll in the running game."

Quarterback Jay Cutler missed on 10 of his first 11 passes, yet the Bears took a 14-3 lead while he was misfiring. Cutler put together a nice drive at the end of the second quarter, firing an 11-yard touchdown pass to Brandon Marshall, but that was about it for rhythm in the passing game. He finished 12 of 26 for 146 yards, but he didn't turn the ball over.

"It wasn't pretty," Cutler said. "I thought the offensive line did a great job. I missed a lot of throws."

Cardinals quarterback Ryan Lindley was benched for Brian Hoyer after the Tillman interception and the Cardinals struggled moving the ball at all, converting only three of 15 third downs. Julius Peppers had a season-high three sacks to give him 111/2, his most in three seasons with the Bears. The biggest play for the Cardinals was Justin Bethel's 82-yard return of a blocked Olindo Mare field-goal attempt.

So, the Bears, thanks in part to the Ravens' victory against the Giants on Sunday, have a chance as they prepare for the Lions. No one knew how they would respond after losing five of their previous six games. Their mantra has been that the playoffs already have started. That is why it wasn't surprising to hear the hollering through the cinder-block walls of the locker room afterward.

"We feel like we have new life," said cornerback Tim Jennings, who returned after missing two games with a dislocated right shoulder. "We forgot what it felt like to be in the win column."

The last time the Bears won in Arizona during the regular season, then-Cardinals coach Denny Green said to "crown their ass!" No one is going to crown these Bears, but they can't be written off either.

"We need some help," Marshall said. "But the only thing we can control is going out there and playing against the Lions."

bmbiggs@tribune.com

Twitter @BradBiggs

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Saudi website editor could face death for apostasy-rights group

RIYADH (Reuters) – The editor of a Saudi Arabian website could be sentenced to death after a judge cited him for apostasy and moved his case to a higher court, the monitoring group Human Rights Watch said on Saturday.

Raif Badawi, who started the Free Saudi Liberals website to discuss the role of religion in Saudi Arabia, was arrested in June, Human Rights Watch said.

Badawi had initially been charged with the less serious offence of insulting Islam through electronic channels, but at a December 17 hearing a judge referred him to a more senior court and recommended he be tried for apostasy, the monitoring group said.

Apostasy, the act of changing religious affiliation, carries an automatic death sentence in Saudi Arabia, along with crimes including blasphemy.

Badawi’s website included articles that were critical of senior religious figures, the monitoring group said.

A spokesman for Saudi Arabia’s Justice Ministry was not available to comment.

The world’s top oil exporter follows the strict Wahhabi school of Islam and applies Islamic law, or sharia.

Judges base their decisions on their own interpretation of religious law rather than on a written legal code or on precedent.

King Abdullah, Saudi Arabia’s ruler, has pushed for reforms to the legal system, including improved training for judges and the introduction of precedent to standardize verdicts and make courts more transparent.

However, Saudi lawyers say that conservatives in the Justice Ministry and the judiciary have resisted implementing many of the changes that he announced in 2007. (Reporting By Angus McDowall; Editing by Kevin Liffey)

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Bethenny Frankel and husband of 2 years separating

LOS ANGELES (AP) — Bethenny Frankel and husband Jason Hoppy are separating.

The 42-year-old TV personality, chef, author and entrepreneur told The Associated Press Sunday that the split brings her “great sadness.”

“This was an extremely difficult decision that as a woman and a mother, I have to accept as the best choice for our family,” Frankel said. “We have love and respect for one another and will continue to amicably co-parent our daughter who is and will always remain our first priority. This is an immensely painful and heartbreaking time for us.”

Frankel and Hoppy were married in 2010 and have a daughter, Bryn, who was born that same year. The couple’s courtship and marriage were documented in two reality series, “Bethenny Getting Married?” and “Bethenny Ever After…” Frankel gained fame as a star of “The Real Housewives of New York City.” Since her stint on the Bravo show, she has written four books, released a fitness video and founded her Skinnygirl line of cocktails, shapewear and nutritional supplements.

She launched a talk show, “Bethenny,” over the summer that is set to air nationally on Fox stations in 2013.

___

AP Entertainment Writer Sandy Cohen is on Twitter: www.twitter.com/APSandy .

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The New Old Age Blog: Fudging the Facts, for Peace of Mind

Lou, my beloved grandfather, lived almost 101 years and obsessively worried every single day of his adult life — probably because his adult life began before it should have. As a child in Russia, he watched helplessly as his mother and sister were killed during a vicious pogrom in their village.

Lou (I called him Zadie) made his way to America, and immediately began imagining the worst about his fate, and his family’s fate, in his new country. I believe Zadie lived as long as he did because he was afraid of what would happen to his children, grandchildren, and great-grandchildren if he wasn’t here to protect them.

When I was a third-year medical student in New York City, he called from Denver very early one morning, waking me and my roommates. He had been listening to his transistor radio on one of his many sleepless nights of worry, and had heard that a Staten Island Ferry boat had crashed, injuring numerous passengers.

There were more than seven million people in the city, and Zadie called at 4 a.m. to make sure I wasn’t one of those injured. It was from him we learned the importance of telling white lies and omitting certain truths with our elderly parents and grandparents.

Before accusing me of infantilizing and patronizing my older family members, hear me out. Anxiety disorders can be debilitating for the elderly. A comprehensive review of the subject found 10 to14 percent of those 65 and older meet the criteria for these diagnoses, a significantly higher figure than for the more widely recognized depression syndromes in the same demographic.

Indeed, depression and anxiety disorders often occur together. Anxiety disorders are underdiagnosed in the elderly, largely because the symptoms are often assumed to be just another manifestation of aging. Additionally, the clinical assessment of the elderly for anxiety is more complicated than for younger patients because the signs may differ from those classically described in the diagnostic manuals.

A large national study showed an increased incidence of general anxiety disorder beginning after age 55, and the National Alliance on Mental Illness notes that, like depression, obsessive-compulsive disorder tends to worsen in old age. Factors contributing to the prevalence and severity of anxiety disorders in the elderly include a host of concomitant medical problems that interact with anxiety in a complicated way.

From the review article cited earlier:

The co-morbidity between medical illness and anxiety disorders poses difficulties for…diagnosis and detection of anxiety. Researchers have suggested that older adults may be more likely to attribute physical symptoms related to anxiety to medical issues… In turn, many physical conditions, such as cardiovascular disease, respiratory disease, hyperthyroidism, and pulmonary and vestibular difficulties, can mimic the symptoms of anxiety…making it difficult to establish the underlying cause…

Furthermore, the symptoms that result from medical illnesses may produce fearful bodily sensations that may result in the subsequent development of anxiety disorders.

As an example, more than 40 percent of patients with Parkinson’s disease meet the criteria for an anxiety disorder. Dementia is also associated with anxiety in a bidirectional way — anxiety can accelerate cognitive decline, which in turn can increase symptoms of anxiety. Added to this morass are the side effects, which can include anxiety, of many medications taken by older patients.

The elderly clearly are an at-risk population for anxiety disorders. Which brings us back to white lies. Zadie’s well-earned anxieties, obsessions and worries accelerated greatly as he got older, and we realized they could largely be prevented if we simply didn’t share the complete truth with him all the time. This became known in our family as the Zadie Filter.

When we took our children to the mountains, we told him we were headed to Colorado Springs; he’d been to Colorado Springs many times and knew it was a flat highway drive from Denver. No high mountain passes or narrow roads without guardrails.

When he begged my sons to become doctors so they would serve behind the front lines in the event they were drafted (this was long after the military draft ended, which was still not reassuring enough for Zadie), they so promised. When our daughter started driving, Zadie warned her it wasn’t safe for a girl to drive alone in case she had car trouble; she promised she would always have company in the car.

Zadie died when his great-grandchildren were still teenagers, and so he never had to know that the boys didn’t go into medicine and that his great-granddaughter drives alone.

My mother, Zadie’s daughter, inherited his anxieties, and as she has entered her mid-80s her symptoms have also markedly increased. On the other side of the family, my mother-in-law’s issues with anxiety began with her Parkinson’s disease and have worsened as her neurological condition has progressed.

With our mothers, we also rely on the Zadie Filter. Our white lies and omissions reduce their worries — which is not to say we can protect them from all triggers (they still read the newspaper and watch the nightly news), but even a bit of relief for them is relief for us as well.

Our parents live for the most part on fixed incomes, so when we’re able to cover some of their expenses without their knowing, we do so, and they worry a little less about their bills. All it takes is a little white lie: “The apartment manager waived your heating bill this month because you’ve been such a good long-term tenant,” or, “Of course I used your credit card when I paid for your medicines.”

My mother accidentally found out that our son broke his finger (playing flag football during finals week!) when a well-intentioned friend asked her how her grandson was doing after his injury. She was upset we hadn’t told her — but only for a few moments, until we explained that it had happened a week before, that he was all splinted up and was in no pain. All of which was 100 percent true, and she didn’t lose a minute of sleep worrying about it.

Last week, after pressing our law student son (he of the broken finger) about a school transcript issue I’ve been worried about for him, he assured me it had been taken care of. Our daughter in grad school goes into bars only when she’s with a large group of friends, and our college son is the designated driver for all of his fraternity functions.

And so it begins.

---

Dr. Harley A. Rotbart is professor and vice chairman of pediatrics at the University of Colorado School of Medicine and the author of “No Regrets Parenting.”

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Kraft targets men, millennials

The pot pie kit comes with pouches of Velveeta cheese, biscuit topping, vegetables and seasoning. The cook sautes chicken until done, then adds milk, vegetables and seasoning, and cooks for another minute. The chicken mixture goes into a baking dish and gets topped with the cheese. Finally, the biscuit mix, to which more milk has been added, goes on the very top. The Velveeta Cheesy Casserole is ready in about 18 minutes at 425 degrees.

Then there's Oscar Mayer's pulled pork that's sold in a clear plastic tub. It's precooked, shredded and seasoned. Kraft is selling the meat without the sauce so cooks can choose their own and add as much as desired.

These and other new products are part of Kraft Foods Group's efforts to attract new customers: millennials and men. The recession disproportionately affected men, who are now doing about 40 percent of the cooking, according to the U.S. Bureau of Labor Statistics.

Northfield-based Kraft has found that both groups are cooking more and looking for flexible recipes, ways to customize their food and have fun in the kitchen. So Kraft is updating its stable of mature brands in ways that appeal to them.

Millennials, age 18 to early 30s, are beginning to cook and don't want to do things like their parents did. So Kraft is offering more products that require some effort. Just not too much effort.

A Kraft study showed younger men cooking even more than their older counterparts — 42 percent of millennial men do all the cooking in the household, while 76 percent do at least some cooking. They also like to experiment with their dishes.

"Now they'll talk about cooking like guys would talk about a hobby 20 years ago," said Barry Calpino, vice president of breakthrough innovation at Kraft. "It's an adventure, it's an experience, it's fun, they talk about 'their signature.'"

Men feel they have more latitude as cooks, according to Robin Ross, associate director of culinary at Kraft. "Women want to please their families and for everyone to like what they make,'' she said. Men, she said, tend not to feel the same pressure. "Men have more of a free hand."

Kraft Foods, a $19 billion a year packaged North American grocery business, was spun off in October from Deerfield-based Mondelez International. Kraft CEO Tony Vernon promised mid-single-digit operating income growth rates for the company, and acknowledged it needs to develop new, more modern products for its brands and increase advertising support to make customers aware of them.

While Vernon hasn't released targets for his ad budget, Kraft has lagged competitors, investing the equivalent of 3 percent of sales toward advertising and marketing, compared with 4.5 percent of sales at competitors, according to the company.

During the company's most recent earnings call, Vernon underscored double-digit sales growth for Lunchables, Velveeta, and MiO, a liquid concentrate used to flavor water, citing new products and subsequent advertising. However, he acknowledged work to do with Jell-O, to capitalize on "yogurt's explosive growth," and with Planters "to re-establish category leadership and profitable growth."

On Friday, Kraft shares closed at $45.53, up 2 percent from the Oct. 1 spinoff.

Simply being a smaller company, Calpino said, means Kraft can lavish attention on brands like Velveeta, which hadn't seen much attention in decades.

"Five or six years ago, I'm not sure we'd do innovation reviews" on Velveeta, Calpino said. "It wasn't even on the list."

Phil Lempert, a supermarket industry expert, said the millennial generation poses challenges for big food companies, which are not known for rapid change. Companies like Kraft, he said, have to "keep it fresh, keep it changing." Young people, he said, "never want to wake up and have the same meal in an entire lifetime.'' He also said that unlike their predecessors, millennials are more interested in "ethnic foods and adventure than ever before."

Lempert said a lot of millennials' tastes are "being driven by food trucks,'' serving products like tacos with a few different meats with a level of high quality and bold flavors. In turn, that has raised millennials' expectations on everything from a restaurant meal to a box of Kraft Macaroni and Cheese.

Lynn Dornblaser, director of innovation and insight at Mintel International, said the fact that Kraft offers some of its new products like easy-to-use, three-pack sauce packets should be a hit because millennials love to cook, but hate to clean.

"Cleaning is a barrier to cooking from scratch," she said. It's the same for male cooks. Even making a white sauce for pasta, Dornblaser said, "you've got dishes to wash, measuring to do, steps to follow."

So products like Kraft's new Velveeta casseroles, pulled pork, Fresh Take cheese and bread crumb mixtures and Velveeta Toppers cheese sauce pouches "offer the ability for consumer to be a little creative with what they're cooking but without too much bother," she said.

Last year, Velveeta launched Cheesy Skillets dinner kits, the brand's biggest launch in more than 20 years. It's a stark departure for a brand best known for Shells & Cheese and its ability to melt over nachos. Consumers saute beef, add cheese sauce from a pouch, cook the pasta, mix, and add hamburger toppings such as shredded lettuce and diced tomato.

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Some states move to ease gun rules

WASHINGTON — As Congress gears up for a fight over possible new gun restrictions, lawmakers in some states have pushed in the opposite direction — to ease gun rules — since the Dec. 14 massacre of 20 first-graders and six women at a school in Newtown, Conn.

None exactly matched the proposal Friday by Wayne LaPierre, head of the National Rifle Assn., to train and deploy armed volunteers to help guard schools around the country.

Legislation has been proposed, however, to allow teachers or other school workers to carry firearms in schools in at least seven states: Missouri, Oklahoma, South Carolina, South Dakota, Tennessee, Texas and Virginia.

"I want a last line of defense," said Jason Villalba, a Republican and newly elected Texas state representative who plans to introduce the Protection of Texas Children Act to allow schools to designate staff members as armed "marshals" provided they undergo special training.

Some lawmakers have gone further, proposing that any teacher with a permit to carry a concealed weapon be allowed to bring it into school.

"It is incredibly irresponsible to leave our schools undefended — to allow mad men to kill dozens of innocents when we have a very simple solution available to us to prevent it," said Oklahoma state Rep. Mark McCullough, a Republican who plans to sponsor legislation to allow teachers and principals to carry firearms in schools after they undergo training.

Several states have pushed for stiffer regulations. In California, lawmakers have proposed strengthening already tough state gun laws, including requiring a permit and background checks for anyone who wants to buy bullets.

Michigan Gov. Rick Snyder, a Republican, vetoed a bill last week that would have allowed gun owners with concealed weapon permits to carry their firearms into schools and other public places. Snyder objected that it didn't let institutions opt out and prohibit weapons on their grounds.

The different legislative responses underscore the difficulty of reaching a political consensus on guns, an issue that often divides lawmakers by geography as much as party affiliation.

Support for gun control measures is much higher in Democratic strongholds in the Northeast and West than in Republican bastions in the Midwest and South, according to polls. But sometimes the divisions are much closer.

Gov. Martin O'Malley of Maryland, a Democrat, complains about "too many guns" and plans to seek gun control legislation.

In neighboring Virginia, Gov. Robert McDonnell, a Republican, said the idea of arming school personnel was worth a discussion.

"If people were armed, not just a police officer but other school officials who were trained and chose to have a weapon, certainly there would have been an opportunity to stop aggressors coming into the school," McDonnell told WTOP radio in Washington.

The idea of arming teachers or administrators has drawn plenty of criticism.

"I've not heard from a single teacher or administrator who said that they want to go to school armed with a gun," said Meg Gruber, president of the Virginia Education Assn.

"Why in the world would you even think of doing this?" added Dennis Van Roekel, president of the National Education Assn. He said Sandy Hook Elementary School in Newtown "did everything right. … But you can't stop somebody with an automatic assault rifle from shooting out a window and coming through."

Betty Olson, a Republican state representative in South Dakota who proposes allowing teachers with concealed weapon permits to bring their firearms into schools, said she had gotten a favorable response.

"We've got a few anti-gun liberals who think that that's crazy, allowing anybody with a gun into the school," she said. "Never mind those lunatics."

South Carolina state Rep. Phillip D. Lowe, a Republican who proposes to allow concealed weapon permit holders who undergo rigorous training to bring guns into school, agreed.

"There's always some people who are opposed to anything with the letters G-U-N," he said.

ALSO:

Boehner's 'fiscal cliff' plan fails

Obama nominates Sen. John Kerry as secretary of State

Obama criticized over Chuck Hagel candidacy for Defense secretary 

richard.simon@latimes.com

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The ‘Teen Mom’ Twitter Proposal

Hmm. Teen mom from Teen Mom Maci Bookout was on Twitter the other day when she received a tweet from the father of her child asking her to marry him. No lie! Ryan Edwards from Teen Dad — Huh? What’s that? There’s no such show? He’s just on Teen Mom? Oh, OK — was all “Maci Bookout marry me!” And Maci was all “Ur s–t got hacked BRO! Outta ur mind haha.” And then Ryan was all “would never let that happen.” Maci asked what he was playing at and then Ryan said, omg, “It means that I want to get on one knee and tell you how much I love you.” Whoaaaa! That’s huge! Maci, marry that boy! He just proposed to you sort of maybe on Twitter! How romantic! Also you have a four-year-old child together so maybe it would be easier to be married, I dunno, for like legal reasons or something? But no. Alas. Maci responded to that saying “Twitter is not the place. Ima kill u.” So wait. If we’re going to take Ryan’s sweet Twitter proposal seriously, which we’re going to, I guess that means we have to take Maci‘s Twitter death threat seriously, too? Police, go arrest Maci. As much as it pains us to say it. Fair’s fair. Ryan, you can marry Maci while she’s in jail. Bentley, which is the name of the child that made all of this, literally all of this, possible, can come live with Ryan while Maci serves her sentence. Sad that such a sweet moment had to end so tragically. But that’s Twitter for you. [Us Weekly]

RELATED: James Franco Has a New Girl

Haha/Ew: Lindsay Lohan said she would not kiss Charlie Sheen when they were filming their scene for Scary Movie 5 because “his mouth grossed her out.” Yes. That’s actually the headline of the TMZ post: “Lindsay REFUSED to Kiss Charlie … Because His Mouth Grossed Her Out.” Man. In a thousand years, when the aliens are sifting through our bones and ashes to learn about the civilization they just annihilated, they’re going to somehow find a list of TMZ headlines and will shake their big gelatinous heads and figure they were right to wipe us out. TMZ headlines. Wooftie. But back to Lindsay, I don’t blame her. You couldn’t pay me a trillion dollars to kiss Charlie Sheen. Why not just pay me ten bucks to lick a wall at the Port Authority? Honestly. Here’s a good line from the story: “we’re told BOTH parties had to sign releases that they didn’t have cold sores.” Which, holy hell, guys. If you have to do that to film a stupid movie, maybe it’s time to pack a suitcase and more to Uruguay. Like, chuck this rotten life aside and say see you soon, Montevideo. You’d be so much happier. It’s supposed to be great down there. It’s time for a change, you guys. Don’t be another TMZ headline. [TMZ]

RELATED: Charlie Sheen and Lindsay Lohan Made Out

Naomi Campbell ate at the new Beatrice Inn on Wednesday night, hobbling in on crutches and in a leg brace after she tore a ligament or something. She ate with Vogue editor Carlyne Cerf de Dudzeele and a photographer named Steven Meisel. At a table nearby, Vera Wang, Calvin Klein, and Donna Karan were all having dinner. Excuse me?? What happened next? Did they all go to a screening of Unzipped and then to the after party, where the Spin Doctors were playing? Was everyone talking about the last MTV Top 20 and if Idalis is better than Daisy Fuentes? I mean, what? Naomi Campbell walks into a restaurant and Calvin Klein, Donna Karan, and Vera freaking Wang are eating nearby? Was Betsey Johnson the busboy? Was Cindy Crawford sweating on the line as a cook? Honestly. I didn’t realize they were still filming Prêt-à-Porter. Good grief. [Page Six]

RELATED: The 2012 Gossip Stories We Loved

Did you know that Kelly Clarkson is engaged to Reba McEntire‘s stepson? Because she is. Kelly Clarkson is engaged to Reba McEntire‘s stepson. So engaged, in fact, that Reba thinks the two might elope. Or at least she “wouldn’t be surprised” if they did. Because some big wedding wouldn’t really be Kelly’s style, apparently. Reba said as much: “That was never my deal and I don’t know that that’s Kelly’s either.” Oh, man. I wish Reba would say “that was never my deal” in a sentence about me. What a nice life Kelly Clarkson has had. Famous from a TV show and then actually famous, respectably famous. And now she gets to marry into Reba McEntire‘s family. It’s all coming together for Kelly Clarkson, guys. Just in time for the end of the world. [Us Weekly]

RELATED: In Which Taylor Swift and One Direction’s Harry Styles Get Serious

Jessica Biel has been doing a tour of Broadway recently. First she went to see Book of Mormon and afterward tweeted thusly: “Book of Mormon was too good for words . . . Except for words like amazing and best musical I’ve seen in forever and incredible!” Which is a totally boring thing to say about Book of Mormon. Here’s the skinny on that show: It’s not that good. Actually, forget the italics. It’s just not that good. Just because a Broadway musical swears and says “scrotum” a lot, does not mean it is being daring or irreverent. It’s a wan show that actually totally gives Mormonism a pass and instead averts your gaze to freaking Africa, which it just makes fun of for two hours because who’s gonna fight back on that one? Toothless and dim, that show. Entertaining, but toothless and dim. Whatever. Jessica Biel then went to go see ScarJo in Cat on a Hot Tin Roof, which good heavens I didn’t know that was in previews already. That is a nightmare. She’s playing Maggie the Cat, ScarJo is. Can you believe that? Well, believe it or not, she is. And Jessica Biel went to go see it. Tellingly, no tweets about that. Ha, not a single damn tweet about that heap. Anyway, all this playgoing has Page Six wondering if J.Biel might be hungry for a Broadway show of her own. Which would be a fine mess, wouldn’t it? Unless they do a Seventh Heaven stage play, something really serious and earnest, in which case I would walk Ms. Biel to the theater myself. But otherwise? Nope. Get thee back to the Stealth 2 set, Biel. Return to where you belong. [Page Six]

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“Twilight Zone” reboot in the works from Bryan Singer, CBS Television Studios

LOS ANGELES (TheWrap.com) – Bryan Singer is about to enter “The Twilight Zone.”

The “X-Men” director is working on a reboot of Rod Serling‘s television series with CBS Television Studios, a spokeswoman for CBS Television Studios told TheWrap. Singer will develop and executive-produce the project, and could direct.

The project is currently in the very early stages.

The original “Twilight Zone” ran on CBS from 1959 to 1964, and the network revived the series in the 1980s. Most recently, the UPN ran a revival of the series, with Forest Whitaker hosting. That version, which launched in 2002, lasted one season.

Singer was also involved in the revival of another classic television series earlier this year, with NBC’s “The Munsters” revamp, dubbed “Mockingbird Lane.” Initially conceived as a series, “Mockingbird Lane” aired as a Halloween special for the network.

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Genetic Gamble : Drugs Aim to Make Several Types of Cancer Self-Destruct

C.J. Gunther for The New York Times

Dr. Donald Bergstrom is a cancer specialist at Sanofi, one of three companies working on a drug to restore a tendency of damaged cells to self-destruct.

For the first time ever, three pharmaceutical companies are poised to test whether new drugs can work against a wide range of cancers independently of where they originated — breast, prostate, liver, lung. The drugs go after an aberration involving a cancer gene fundamental to tumor growth. Many scientists see this as the beginning of a new genetic age in cancer research.

Great uncertainties remain, but such drugs could mean new treatments for rare, neglected cancers, as well as common ones. Merck, Roche and Sanofi are racing to develop their own versions of a drug they hope will restore a mechanism that normally makes badly damaged cells self-destruct and could potentially be used against half of all cancers.

No pharmaceutical company has ever conducted a major clinical trial of a drug in patients who have many different kinds of cancer, researchers and federal regulators say. “This is a taste of the future in cancer drug development,” said Dr. Otis Webb Brawley, the chief medical and scientific officer of the American Cancer Society. “I expect the organ from which the cancer came from will be less important in the future and the molecular target more important,” he added.

And this has major implications for cancer philanthropy, experts say. Advocacy groups should shift from fund-raising for particular cancers to pushing for research aimed at many kinds of cancer at once, Dr. Brawley said. John Walter, the chief executive officer of the Leukemia and Lymphoma Society, concurred, saying that by pooling forces “our strength can be leveraged.”

At the heart of this search for new cancer drugs are patients like Joe Bellino, who was a post office clerk until his cancer made him too sick to work. Seven years ago, he went into the hospital for hernia surgery, only to learn he had liposarcoma, a rare cancer of fat cells. A large tumor was wrapped around a cord that connects the testicle to the abdomen. “I was shocked,” he said in an interview this summer.

Companies have long ignored liposarcoma, seeing no market for drugs to treat a cancer that strikes so few. But it is ideal for testing Sanofi’s drug because the tumors nearly always have the exact genetic problem the drug was meant to attack — a fusion of two large proteins. If the drug works, it should bring these raging cancers to a halt. Then Sanofi would test the drug on a broad range of cancers with a similar genetic alteration. But if the drug fails against liposarcoma, Sanofi will reluctantly admit defeat.

“For us, this is a go/no-go situation,” said Laurent Debussche, a Sanofi scientist who leads the company’s research on the drug.

The genetic alteration the drug targets has tantalized researchers for decades. Normal healthy cells have a mechanism that tells them to die if their DNA is too badly damaged to repair. Cancer cells have grotesquely damaged DNA, so ordinarily they would self-destruct. A protein known as p53 that Dr. Gary Gilliland of Merck calls the cell’s angel of death normally sets things in motion. But cancer cells disable p53, either directly, with a mutation, or indirectly, by attaching the p53 protein to another cellular protein that blocks it. The dream of cancer researchers has long been to reanimate p53 in cancer cells so they will die on their own.

The p53 story began in earnest about 20 years ago. Excitement ran so high that, in 1993, Science magazine anointed it Molecule of the Year and put it on the cover. An editorial held out the possibility of “a cure of a terrible killer in the not too distant future.”

Companies began chasing a drug to restore p53 in cells where it was disabled by mutations. But while scientists know how to block genes, they have not figured out how to add or restore them. Researchers tried gene therapy, adding good copies of the p53 gene to cancer cells. That did not work.

Then, instead of going after mutated p53 genes, they went after half of cancers that used the alternative route to disable p53, blocking it by attaching it to a protein known as MDM2. When the two proteins stick together, the p53 protein no longer functions. Maybe, researchers thought, they could find a molecule to wedge itself between the two proteins and pry them apart.

The problem was that both proteins are huge and cling tightly to each other. Drug molecules are typically tiny. How could they find one that could separate these two bruisers, like a referee at a boxing match?

In 1996, researchers at Roche noticed a small pocket between the behemoths where a tiny molecule might slip in and pry them apart. It took six years, but Roche found such a molecule and named it Nutlin because the lab was in Nutley, N.J.

But Nutlins did not work as drugs because they were not absorbed into the body.

Roche, Merck and Sanofi persevered, testing thousands of molecules.

At Sanofi, the stubborn scientist leading the way, Dr. Debussche, maintained an obsession with p53 for two decades. Finally, in 2009, his team, together with Shaomeng Wang at the University of Michigan and a biotech company, Ascenta Therapeutics, found a promising compound.

The company tested the drug by pumping it each day into the stomachs of mice with sarcoma.

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Stores hope last-minute Christmas shoppers revive holiday sales

With three days left until Christmas, last-minute shoppers are surging into malls in a mad dash for gifts as retailers extend store hours and trot out steep discounts in a final holiday-season push.

Merchants are hoping procrastinators will give them a boost this weekend. Many stores saw a worrying drop in sales in recent weeks after a robust start on Black Friday. Several are rolling out promotions as they try to make up for lost steam.

Toys R Us stores nationwide began an 88-hour, all-day-all-night marathon Friday that continues until 10 p.m. Christmas Eve. Macy's is welcoming shoppers for 48 straight hours at most of its stores on this final weekend before Christmas. Target is staying open until midnight Sunday.

At the Grove shopping center in Los Angeles' Fairfax district, shoppers swarmed the stores and cars jammed the parking lots. Christmas carols blasted from speakers. And fake reindeer and a sleigh arced overhead.

"The panic is coming in waves," sighed Angie Hill, 44, of Huntington Beach. "I've barely just started. There's still a lot of people left to buy gifts for."

The marketing director said she normally starts shopping weeks before Christmas, but a new job left her with little free time. She pointed to bags holding a magic kit for her son and exercise clothes for her husband — the very first gifts she had bought for the big day. "My shopping list is getting bigger every minute."

She's not alone. Two-thirds of Americans — 132 million people — haven't yet finished their holiday shopping, according to a survey released this week by Consumer Reports. About 14% have yet to start buying gifts, and 9% — or 17 million people — will still be rushing to cross items off their Christmas lists on Christmas Eve.

"People are very focused. They have their list and it's bam, bam, bam! They are trying to check off what they need, get in and get out," said Kim Freeburn, a district vice president of Macy's stores. "It's an intense customer this weekend."

Both the Grove and the Americana at Brand shopping mall in Glendale have been besieged with shoppers over the last few weeks and expect a similar surge in the last few days before Christmas, said Paul Kurzawa, chief operating officer of Caruso Affiliated, which owns both shopping centers.

"The last few weeks have been phenomenal, and this weekend is a continuation of that as people rush in for last-minute gift buying," he said. "You have the last weekend and you get an extra bite on Monday as well."

So far, the average American has spent $340 on presents, the Consumer Reports survey said. An earlier report from Gallup found that shoppers planned to shell out $770 apiece for the holiday. The National Retail Federation predicted total holiday spending of $586.1 billion this year, up 4.1% from last year. It's a crucial time for merchants, which can make up to 40% of their annual sales during the season.

"Holiday sales have been off for weeks," said Marshal Cohen, chief industry analyst at NPD Group. He blamed a lack of exciting merchandise and a hyped-up Black Friday that may have pulled sales earlier into the season. "The bad news is this year will be based on price more than merchandise, as consumers have been groomed to wait to be rewarded with better discounts."

CeCe Solorzano, 30, says she always waits until the weekend before Christmas to scoop up the best discounts.

"I'm going to shop all day tomorrow and the weekend. Hopefully I'll be done on the 24th of December," said the Santa Clarita marketing specialist, who has to find presents for a dozen friends and family members. "I've really waited until the last possible moment this year, but the longer you wait, the better the deals."

Target just rolled out its "Last Minute Sale" that will run until Christmas Eve and is focused on popular gadgets and toys such as iPod Nanos and Easy-Bake Ovens.

"We see those last-minute panicked guests" but also shoppers buying treats for themselves, spokeswoman Donna Egan said. "We try to accommodate the surge of guests, procrastinators or not."

At the Best Buy store in Westfield Culver City, there will be one cash register on Christmas Eve dedicated just to buying gift cards, general manager Margie Kenney said. "It's a huge day for gift cards," she said. "Everything is out of stock, so you're like, 'Give me a gift card.'"

Unless shoppers this weekend go over the top, it's shaping up to be a modest holiday season, said Kamalesh Rao, director of economic research at MasterCard Advisors SpendingPulse.

"That's in keeping with retail sales growth this year," he said. "There is a possibility if you have a strong weekend it could make up a little bit, since the last couple of days is pretty important, especially for sectors like jewelry."

Expect to see Christian Moreno, 43, and his wife, Hilda, out at the malls every day until Dec. 25. Between their two families, the couple have 34 people to shop for every year.

"We're a huge family," said Moreno, who works as a superintendent at the L.A. and Ontario international airports. "It's a lot of presents left to find."

shan.li@latimes.com

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